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Listen "🧓 Macrophages Lost, 💉 Capillaries Impaired, 🔄 Aging Accelerated"
Episode Synopsis
🧓 Aging skin, fading flow. This 2025 Nature study uncovers how dermal capillary-associated macrophages (CAMs) decline with age—preceding microvascular dysfunction and impaired blood flow. 🧬 Using intravital imaging and macrophage fate mapping in mice (and validating in humans!), the authors reveal that CAMs are not replenished unless triggered by injury or CSF1. 🛠️ Fascinatingly, local CSF1–Fc therapy restored CAMs and rejuvenated perfusion in aged skin. A compelling case for targeting tissue-resident immunity! 🩸 📖 doi:10.1038/s41586-025-09639-y
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