Parkinson’s is often framed as a brain-first disorder, but some of its earliest changes unfold in the gut. This episode unpacks a global metagenomic analysis showing that two surprisingly ordinary microbial compounds, ones most people consume every day, quietly disappear in Parkinson’s. When these pathways vanish, gut defenses weaken, protective metabolites fall, and enteric neurons may become vulnerable to the toxins that start pathology long before tremors appear.The goal: reveal how the loss of these two everyday compounds reshapes gut biology in ways that could precede neurodegeneration, and clarify why restoring their microbial pathways may be far more important than previously recognized.00:00 A Different Origin Story for Parkinson’s00:33 Early Clues That Don’t Start in the Brain01:15 A Possible Route From Gut to Brain02:10 The Missing Pathways No One Expected02:59 What a Six-Country Analysis Revealed05:07 How These Lost Functions Reshape Gut Biology08:33 What This Means for Prevention and Intervention10:53 Closing the Loop: Why the Gut MattersPMID: 37314861

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