ALS Untangled Series: Ep. 34 - Ursodiol

CReATe Podcast
22/08/2020 14 min
ALS Untangled Series: Ep. 34 - Ursodiol

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Episode Synopsis

Ursodiol or ursodeoxycholic acid (UDCA) is a bile acid derivative of cholesterol. Since it can have antioxidant, anti-inflammatory and anti-apoptotic effects, it has mechanisms by which it could slow ALS progression. Here we discuss trials of UDCA in PALS, including the taurine-conjugated form (TUDCA). Some of these trials came out after our ALSUntangled review, and have changed our opinion about UDCA as an ALS treatment.

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