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Listen "TNNT2 Variant Pinpoints Low-Risk Hypertrophic Cardiomyopathy 12/04/25"
Episode Synopsis
Welcome to Cardiology Today – Recorded December 04, 2025. This episode summarizes 5 key cardiology studies on topics like oral magnesium and diabetes mellitus. Key takeaway: TNNT2 Variant Pinpoints Low-Risk Hypertrophic Cardiomyopathy.
Article Links:
Article 1: Oral magnesium and outcomes in US veterans with heart failure. (European heart journal)
Article 2: Diabetes and sudden cardiac death: a Danish nationwide study. (European heart journal)
Article 3: Cardiovascular-Kidney-Metabolic Disease Burden in Children and Adults Following Heart Transplantation. (JACC. Heart failure)
Article 4: The p.Asn271Ile Variant in the TNNT2 Gene Is Associated With Low-Risk Late-Onset Hypertrophic Cardiomyopathy. (JACC. Heart failure)
Article 5: Outcomes After Donation After Circulatory Determination of Death Cardiac Transplantation: An International, Multicenter Retrospective Study. (JACC. Heart failure)
Full episode page: https://podcast.explainheart.com/podcast/tnnt2-variant-pinpoints-low-risk-hypertrophic-cardiomyopathy-12-04-25/
Featured Articles
Article 1: Oral magnesium and outcomes in US veterans with heart failure.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41338273
Summary: This study identified 54696 United States veterans with Heart Failure between 2001 and 2023 who also presented with hypomagnesemia, defined as serum magnesium below 1.7 milligrams per deciliter. Among this cohort, 10695 patients were initiated on oral magnesium therapy, with a median daily dose of 420 milligrams. A propensity score-matched cohort of 21098 patients was established, allowing for comparison of clinical outcomes between those receiving oral magnesium and those not. The study thus provided the foundational data and a robust comparative structure for evaluating the real-world impact of oral magnesium supplementation in this population.
Article 2: Diabetes and sudden cardiac death: a Danish nationwide study.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41338249
Summary: This nationwide Danish study included the entire Danish population in 2010 as its cohort for analysis of sudden cardiac death. Sudden cardiac death cases were ascertained using detailed Danish death certificates across the population. The research characterized incidence rates of sudden cardiac death among individuals with type one diabetes and type two diabetes. The study additionally quantified the shortened life expectancy attributed to sudden cardiac death within these specific diabetic populations.
Article 3: Cardiovascular-Kidney-Metabolic Disease Burden in Children and Adults Following Heart Transplantation.
Journal: JACC. Heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41117724
Summary: This study characterized the incidence and prevalence of cardiovascular-kidney-metabolic dysfunction in children and adults following heart transplantation. The research developed an expanded understanding of these specific post-transplant complications. This characterization provides critical information for informing screening and therapeutic strategies to mitigate adverse events in heart transplant recipients.
Article 4: The p.Asn271Ile Variant in the TNNT2 Gene Is Associated With Low-Risk Late-Onset Hypertrophic Cardiomyopathy.
Journal: JACC. Heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40310325
Summary: This study demonstrated a founder effect of the cardiac troponin T gene p.Asn271Ile variant in A Coruña, Spain. It characterized the specific phenotype of the p.Asn271Ile variant. The research compared this phenotype with codon 92 variants, a known hotspot associated with high risk hypertrophic cardiomyopathy. The data indicated that the TNNT2 p.Asn271Ile variant is associated with low-risk late-onset hypertrophic cardiomyopathy.
Article 5: Outcomes After Donation After Circulatory Determination of Death Cardiac Transplantation: An International, Multicenter Retrospective Study.
Journal: JACC. Heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40293864
Summary: This international, multicenter retrospective study compared outcomes of heart transplantation after Donation After Circulatory Determination of Death across Europe and the United States. The study evaluated differences between recipients whose donor hearts were retrieved using thoraco-abdominal normothermic regional perfusion. It also assessed outcomes for those whose hearts were recovered using direct procurement and perfusion. The research established findings regarding the most clinically effective method of organ procurement for Donation After Circulatory Determination of Death heart transplantation.
Transcript
Today’s date is December 04, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Oral magnesium and outcomes in US veterans with heart failure. This study identified 54696 United States veterans with Heart Failure between 2001 and 2023 who also presented with hypomagnesemia, defined as serum magnesium below 1.7 milligrams per deciliter. Among this cohort, 10695 patients were initiated on oral magnesium therapy, with a median daily dose of 420 milligrams. A propensity score-matched cohort of 21098 patients was established, allowing for comparison of clinical outcomes between those receiving oral magnesium and those not. The study thus provided the foundational data and a robust comparative structure for evaluating the real-world impact of oral magnesium supplementation in this population.
Article number two. Diabetes and sudden cardiac death: a Danish nationwide study. This nationwide Danish study included the entire Danish population in 2010 as its cohort for analysis of sudden cardiac death. Sudden cardiac death cases were ascertained using detailed Danish death certificates across the population. The research characterized incidence rates of sudden cardiac death among individuals with type one diabetes and type two diabetes. The study additionally quantified the shortened life expectancy attributed to sudden cardiac death within these specific diabetic populations.
Article number three. Cardiovascular-Kidney-Metabolic Disease Burden in Children and Adults Following Heart Transplantation. This study characterized the incidence and prevalence of cardiovascular-kidney-metabolic dysfunction in children and adults following heart transplantation. The research developed an expanded understanding of these specific post-transplant complications. This characterization provides critical information for informing screening and therapeutic strategies to mitigate adverse events in heart transplant recipients.
Article number four. The p.Asn271Ile Variant in the TNNT2 Gene Is Associated With Low-Risk Late-Onset Hypertrophic Cardiomyopathy. This study demonstrated a founder effect of the cardiac troponin T gene p.Asn271Ile variant in A Coruña, Spain. It characterized the specific phenotype of the p.Asn271Ile variant. The research compared this phenotype with codon 92 variants, a known hotspot associated with high risk hypertrophic cardiomyopathy. The data indicated that the TNNT2 p.Asn271Ile variant is associated with low-risk late-onset hypertrophic cardiomyopathy.
Article number five. Outcomes After Donation After Circulatory Determination of Death Cardiac Transplantation: An International, Multicenter Retrospective Study. This international, multicenter retrospective study compared outcomes of heart transplantation after Donation After Circulatory Determination of Death across Europe and the United States. The study evaluated differences between recipients whose donor hearts were retrieved using thoraco-abdominal normothermic regional perfusion. It also assessed outcomes for those whose hearts were recovered using direct procurement and perfusion. The research established findings regarding the most clinically effective method of organ procurement for Donation After Circulatory Determination of Death heart transplantation.
Thank you for listening. Don’t forget to subscribe.
Keywords
oral magnesium, diabetes mellitus, type two diabetes, cardiovascular-kidney-metabolic dysfunction, thoraco-abdominal normothermic regional perfusion, genetic mutation, TNNT2 gene, C. K. M. disease, children, p.Asn271Ile variant, clinical outcomes, life expectancy, founder effect, adults, Donation After Circulatory Determination of Death, organ procurement, direct procurement and perfusion, United States veterans, heart failure, sudden cardiac death, heart transplantation, hypertrophic cardiomyopathy, type one diabetes, hypomagnesemia.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post TNNT2 Variant Pinpoints Low-Risk Hypertrophic Cardiomyopathy 12/04/25 first appeared on Cardiology Today.
Article Links:
Article 1: Oral magnesium and outcomes in US veterans with heart failure. (European heart journal)
Article 2: Diabetes and sudden cardiac death: a Danish nationwide study. (European heart journal)
Article 3: Cardiovascular-Kidney-Metabolic Disease Burden in Children and Adults Following Heart Transplantation. (JACC. Heart failure)
Article 4: The p.Asn271Ile Variant in the TNNT2 Gene Is Associated With Low-Risk Late-Onset Hypertrophic Cardiomyopathy. (JACC. Heart failure)
Article 5: Outcomes After Donation After Circulatory Determination of Death Cardiac Transplantation: An International, Multicenter Retrospective Study. (JACC. Heart failure)
Full episode page: https://podcast.explainheart.com/podcast/tnnt2-variant-pinpoints-low-risk-hypertrophic-cardiomyopathy-12-04-25/
Featured Articles
Article 1: Oral magnesium and outcomes in US veterans with heart failure.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41338273
Summary: This study identified 54696 United States veterans with Heart Failure between 2001 and 2023 who also presented with hypomagnesemia, defined as serum magnesium below 1.7 milligrams per deciliter. Among this cohort, 10695 patients were initiated on oral magnesium therapy, with a median daily dose of 420 milligrams. A propensity score-matched cohort of 21098 patients was established, allowing for comparison of clinical outcomes between those receiving oral magnesium and those not. The study thus provided the foundational data and a robust comparative structure for evaluating the real-world impact of oral magnesium supplementation in this population.
Article 2: Diabetes and sudden cardiac death: a Danish nationwide study.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41338249
Summary: This nationwide Danish study included the entire Danish population in 2010 as its cohort for analysis of sudden cardiac death. Sudden cardiac death cases were ascertained using detailed Danish death certificates across the population. The research characterized incidence rates of sudden cardiac death among individuals with type one diabetes and type two diabetes. The study additionally quantified the shortened life expectancy attributed to sudden cardiac death within these specific diabetic populations.
Article 3: Cardiovascular-Kidney-Metabolic Disease Burden in Children and Adults Following Heart Transplantation.
Journal: JACC. Heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41117724
Summary: This study characterized the incidence and prevalence of cardiovascular-kidney-metabolic dysfunction in children and adults following heart transplantation. The research developed an expanded understanding of these specific post-transplant complications. This characterization provides critical information for informing screening and therapeutic strategies to mitigate adverse events in heart transplant recipients.
Article 4: The p.Asn271Ile Variant in the TNNT2 Gene Is Associated With Low-Risk Late-Onset Hypertrophic Cardiomyopathy.
Journal: JACC. Heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40310325
Summary: This study demonstrated a founder effect of the cardiac troponin T gene p.Asn271Ile variant in A Coruña, Spain. It characterized the specific phenotype of the p.Asn271Ile variant. The research compared this phenotype with codon 92 variants, a known hotspot associated with high risk hypertrophic cardiomyopathy. The data indicated that the TNNT2 p.Asn271Ile variant is associated with low-risk late-onset hypertrophic cardiomyopathy.
Article 5: Outcomes After Donation After Circulatory Determination of Death Cardiac Transplantation: An International, Multicenter Retrospective Study.
Journal: JACC. Heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40293864
Summary: This international, multicenter retrospective study compared outcomes of heart transplantation after Donation After Circulatory Determination of Death across Europe and the United States. The study evaluated differences between recipients whose donor hearts were retrieved using thoraco-abdominal normothermic regional perfusion. It also assessed outcomes for those whose hearts were recovered using direct procurement and perfusion. The research established findings regarding the most clinically effective method of organ procurement for Donation After Circulatory Determination of Death heart transplantation.
Transcript
Today’s date is December 04, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Oral magnesium and outcomes in US veterans with heart failure. This study identified 54696 United States veterans with Heart Failure between 2001 and 2023 who also presented with hypomagnesemia, defined as serum magnesium below 1.7 milligrams per deciliter. Among this cohort, 10695 patients were initiated on oral magnesium therapy, with a median daily dose of 420 milligrams. A propensity score-matched cohort of 21098 patients was established, allowing for comparison of clinical outcomes between those receiving oral magnesium and those not. The study thus provided the foundational data and a robust comparative structure for evaluating the real-world impact of oral magnesium supplementation in this population.
Article number two. Diabetes and sudden cardiac death: a Danish nationwide study. This nationwide Danish study included the entire Danish population in 2010 as its cohort for analysis of sudden cardiac death. Sudden cardiac death cases were ascertained using detailed Danish death certificates across the population. The research characterized incidence rates of sudden cardiac death among individuals with type one diabetes and type two diabetes. The study additionally quantified the shortened life expectancy attributed to sudden cardiac death within these specific diabetic populations.
Article number three. Cardiovascular-Kidney-Metabolic Disease Burden in Children and Adults Following Heart Transplantation. This study characterized the incidence and prevalence of cardiovascular-kidney-metabolic dysfunction in children and adults following heart transplantation. The research developed an expanded understanding of these specific post-transplant complications. This characterization provides critical information for informing screening and therapeutic strategies to mitigate adverse events in heart transplant recipients.
Article number four. The p.Asn271Ile Variant in the TNNT2 Gene Is Associated With Low-Risk Late-Onset Hypertrophic Cardiomyopathy. This study demonstrated a founder effect of the cardiac troponin T gene p.Asn271Ile variant in A Coruña, Spain. It characterized the specific phenotype of the p.Asn271Ile variant. The research compared this phenotype with codon 92 variants, a known hotspot associated with high risk hypertrophic cardiomyopathy. The data indicated that the TNNT2 p.Asn271Ile variant is associated with low-risk late-onset hypertrophic cardiomyopathy.
Article number five. Outcomes After Donation After Circulatory Determination of Death Cardiac Transplantation: An International, Multicenter Retrospective Study. This international, multicenter retrospective study compared outcomes of heart transplantation after Donation After Circulatory Determination of Death across Europe and the United States. The study evaluated differences between recipients whose donor hearts were retrieved using thoraco-abdominal normothermic regional perfusion. It also assessed outcomes for those whose hearts were recovered using direct procurement and perfusion. The research established findings regarding the most clinically effective method of organ procurement for Donation After Circulatory Determination of Death heart transplantation.
Thank you for listening. Don’t forget to subscribe.
Keywords
oral magnesium, diabetes mellitus, type two diabetes, cardiovascular-kidney-metabolic dysfunction, thoraco-abdominal normothermic regional perfusion, genetic mutation, TNNT2 gene, C. K. M. disease, children, p.Asn271Ile variant, clinical outcomes, life expectancy, founder effect, adults, Donation After Circulatory Determination of Death, organ procurement, direct procurement and perfusion, United States veterans, heart failure, sudden cardiac death, heart transplantation, hypertrophic cardiomyopathy, type one diabetes, hypomagnesemia.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post TNNT2 Variant Pinpoints Low-Risk Hypertrophic Cardiomyopathy 12/04/25 first appeared on Cardiology Today.
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