Matthew and Brian join us today for an insightful discussion discussing the pivotal role of evidence-based medicine, a cornerstone in optimizing patient outcomes and healthcare strategies. This conversation navigates through the historical tapestry of medical research, spotlighting James Lind’s 1753 seminal scurvy experiment as a monumental benchmark initiating systematic medical experimentation. We dissect the principle of equipoise, a crucial element ensuring the ethical integrity and scientific validity of clinical trials, and venture into addressing the frequent anxieties patients encounter regarding clinical trials, providing actionable strategies for fostering critical thinking in health information to address the growing scientific skepticism. Underscoring the transformative impact of patient involvement in accelerating advancements within clinical trials and overarching medical research, affirming its instrumental role in shaping the future of healthcare.



Dr. Brian Burnette is a physician at Green Bay Oncology. He graduated top of his class from the College of Human Medicine at Michigan State University. Afterward, he completed his internship, residency, and fellowship at the Mayo Clinic, where he also recently served as an Instructor of Medicine. With a special interest in lymphoid malignancies, Brian has authored multiple full-length, peer-reviewed articles addressing various cancer types and treatments.



Dr. Matthew Ryan is a physician at Green Bay Oncology. He holds a Bachelor’s degree in Aerospace Engineering from Iowa State University. He attended medical school at the University of Iowa and completed his residency and fellowships in oncology and hematology at the Mayo Clinic in Rochester, Minnesota. While at the Mayo Clinic, Matthew also developed clinical practice guidelines for its oncology tumor group.



“The real heroes in clinical research are those patients who invested in their own care and in the care of future patients; it’s on their backs that these clinical trials led to improvements in cancer care.” – Brian Burnette



This week on Cancer Covered:A brief history of medical research and experimentationThe historical perception of ideas without evidence as “medieval”The slow progress of medical experimentation and the reluctance to abandon entrenched ideasNazi World War II experiments, the Tuskegee syphilis experiment, and other ethical concerns on medical experimentsThe importance of informed consentEquipoise in research and randomization in clinical trialsThe rarity of placebo-controlled trialsThe British Parachute papersCommon anxieties about participating in clinical researchThe rigorous process and ethical standards in modern clinical trials.The courage of individuals who participated in early clinical trials for cancerThe importance of cooperation among competitive researchers in standardizing treatments and sharing resourcesThe value of taxpayer-funded clinical trialsThe potential shortcomings of today’s clinical trial structureBernard Fisher and his leadership in developing clinical trials for breast cancerThe economic impact of clinical researchThe role of clinical research in job creation and generating economic activityThe use of surrogate endpoints and other approaches to shortening timelines for cancer clinical trialsThe role of patient advocates in the development of clinical trialsThe anti-intellectual and anti-science backlashThe difference between good and bad skepticismPatient-centered care and supporting patients in their treatment choices



Connect with Dr. Matthew Ryan:Matthew Ryan on LinkedIn



Connect with Dr. Brian BurnetteBrian Burnette Website



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