Louisville's star running back, Isaac Brown, suffered a lower leg injury, potentially sidelining him for several games. Brown, leading the nation in yards per carry, has been a significant factor in the Cardinals' offense. With Brown out, the team will rely on Keyjuan Brown, their second-leading rusher. The injury has shifted the betting line, and Louisville aims to maintain their ACC championship hopes and College Football Playoff aspirations despite the setback.The Daily News Now! - Every city. Every story. AI-powered. Hosted on Acast. See acast.com/privacy for more information.

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