Send us a text🧠 Clinical Context:For patients who absolutely cannot tolerate statins — despite trying multiple options or experiencing severe side effects.Reminder: Always try multiple statins first (different types, dosages, timing) before declaring “statin intolerance.”💊 What is Bempedoic Acid?Non-statin oral agent, works upstream of HMG-CoA reductase.Liver-activated – avoids muscle toxicity seen in statins.First oral non-statin to reduce MACE-4 endpoints.📈 Clinical Impact:LDL-C reduction: 20–25%.Cardiovascular events:23% ↓ in MI.19% ↓ in coronary revascularization.⚠️ Adverse Effects:Gout, gallstones, elevated transaminases.Avoid if history of uric acid disorders.🧩 Clinical Takeaway:Great adjunct to maximally tolerated statin or for rare, true statin-intolerant patients.Not first-line — statins remain king, with 40–50% LDL reduction.

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