🎙️ Episode 25: Methotrexate for OA Pain? Believe It or Not

Brilliant Board Review & CME
20/04/2025 3 min Temporada 1 Episodio 25
🎙️ Episode 25: Methotrexate for OA Pain? Believe It or Not

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Episode Synopsis

Send us a text🧠 Surprising contender:OA is not just wear-and-tear — there's an inflammatory phenotype.🧪 Trial:MTX 10–25 mg/week in knee OA with persistent pain.Significant ↓ pain and improved function vs placebo.⚠️ Side Effects:GI upset, mouth ulcers, fatigue.Hepatotoxicity, myelosuppression, pulmonary fibrosis (rare).Always co-prescribe folic acid.🧩 Clinical Takeaway:Consider in refractory OA when NSAIDs, injections, and PT have failed.Especially useful when opioids are not an option.

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