In this episode, our guests are joined my NAMSA’s Melissa Cadaret to discuss the ever-confusing cytotoxicity failure.  Manufacturers can have more questions created when encountering an unexpected cytotoxicity result and these podcast experts have seen thousands of various cytotoxicity results.  The information provided from a cytotoxicity test can be useful and stressful, so what do manufacturers need to know to navigate the cyto failure, whether expected or unexpected.“I would say we generally see some type of cytotoxicity failure weekly.” –Melissa Cadaret “Cytotoxicity is not really an end point. It’s a screen.” – Sheri Krajewski-Bibins“It is what it is and it is what it’s not.” – Don Pohl“It’s the only biological effect listed as an overall screen for biocompatibility.” – Don Pohl“Things like copper, and antimicrobials really wreak havoc and contribute to a lot of cytotoxicity failures.  Some of your residues from your cleaning and in processing aspect are also a huge culprit.”  Melissa Cadaret “It might have been expected.  You can get pretty good at predicting cytotoxicity.” – Don PohlDiscussion points include: What does it mean when one receives a failed cyto result What is the useful information you can gather from a cytotoxicity testWhat typical materials and devices may have problems with a cytotoxicity testWhat to do if you know your material is going to fail cyto

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