In this engaging fireside chat, Dr. Matthew Strickland, MD and Leslie Swanson, ARNP, delve into the treatment of advanced gastric and GEJ cancers. They present two distinct patient cases, highlighting critical aspects from initial diagnosis and biomarker profiling (including HER2, PD-L1, MSI, and CLDN18.2 status) to real-world treatment challenges and long-term management. The conversation explores decision-making processes, the nuances of managing infusion-related side effects with agents like zolbetuximab, and the importance of multidisciplinary collaboration and shared decision-making for optimal patient outcomes. 

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