I'm frequently asked if H2 blockers are safer than PPIs.Let's take a look.To review the dangers of PPIs first, they are associated with the following:Nutrient deficienciesGut microbiome disruptionInfectionsDepression and AnxietyLoss of libidoKidney problemsOsteoporosisStroke, heart attack riskStomach cancer, and more...H2 blocks work by this mechanism: They block histamine-induced acid secretion in your stomach. Histamine triggers your stomach cells (parietal cells) to release acid by activating H2 receptors. These drugs block that mechanism.H2 blockers are less potent than PPIs and are best for mild to moderate reflux or nighttime symptoms. Overall they are used to accomplish moderate acid reduction.The acts faster than PPIs (within 1 hour) but lasts for a shorter period of time (6 to 12 hours vs 24 hours with a PPI).Side effects are: headaches, constipation, diarrhea, fatigue, dizziness, muscle aches and confusion in the elderly.Long-term side effects include:Vitamin B12 deficiency (same as a PPI)Increased risk of infections, though less severe than with a PPIKidney and mood changes are considered rareMicrobiome disruption - all less than with a PPIAnother factor is that tolerance builds over time with H2 blockers reducing their effectiveness.As you can see, there are still dangers, and for those with more severe reflux, H2 blockers won't provide the relief needed.The best goal is to identify the root cause of the reflux and thereby be able to wean off the medication. The side effects are too severe to be ignored.If you'd like help we're here for you. The best next step is to contact us for a consultation and then we can determine if what we do is a good fit for you. Call 727-335-0400.#acidreflux #hiatalhernia #rootcausemedicine

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