This week’s episode explores the complex world of itch and pruritus — and why it’s not all about histamine. We break down how chronic itch can stem from immune dysregulation and cytokine activity, not just allergic reactions. Patients with chronic itch often face stigma, being told it’s “in their head,” but the truth is far deeper. We discuss how autoimmune factors, neurochemical pathways, and environmental triggers can heighten itch sensitivity and why it’s crucial to take these patients seriously.Learn how to properly assess and treat itch beyond antihistamines, and why understanding the immune and chemical landscape of pruritus is key to effective dermatologic care.

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