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Listen "Y2-Receptor Blockade Quells Ventricular Arrhythmias. 10/08/25"
Episode Synopsis
Welcome to Cardiology Today – Recorded October 08, 2025. This episode summarizes 5 key cardiology studies on topics like Ventricular arrhythmias and blood pressure monitoring. Key takeaway: Y2-Receptor Blockade Quells Ventricular Arrhythmias..
Article Links:
Article 1: Chronotherapy as a novel strategy to limit anthracycline-induced cardiotoxicity. (Cardiovascular research)
Article 2: Sympathovagal crosstalk: Y2-receptor blockade enhances vagal effects which in turn Reduce NPY levels via muscarinic receptor activation. (Cardiovascular research)
Article 3: Blood Pressure 15 to 90 Days After a Hypertensive Disorder of Pregnancy and Later Hypertension. (Hypertension (Dallas, Tex. : 1979))
Article 4: Adaptation to Elevated Mitochondrial Calcium Is Distinct in the Left and Right Ventricles. (Circulation research)
Article 5: Closed-Loop Vagus Nerve Stimulation Delivered With a Miniaturized System Produces Lasting Recovery in Individuals With Chronic Stroke. (Stroke)
Full episode page: https://podcast.explainheart.com/podcast/y2-receptor-blockade-quells-ventricular-arrhythmias-10-08-25/
Featured Articles
Article 1: Chronotherapy as a novel strategy to limit anthracycline-induced cardiotoxicity.
Journal: Cardiovascular research
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41052913
Summary: This review article proposes chronomodulated chemotherapy as a preventive strategy to mitigate anthracycline-induced cardiotoxicity. It highlights that adjusting anthracycline administration time to the body’s circadian rhythms may reduce the risk of heart failure in cancer patients and survivors. The concept is based on the significant role of circadian rhythms in cardiovascular physiology, suggesting a time-dependent variation in cardiac sensitivity to these chemotherapeutic agents.
Article 2: Sympathovagal crosstalk: Y2-receptor blockade enhances vagal effects which in turn Reduce NPY levels via muscarinic receptor activation.
Journal: Cardiovascular research
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41052902
Summary: This study investigates the intricate sympathovagal crosstalk involved in ventricular arrhythmias, focusing on the role of neuropeptide Y. Researchers found that vagal nerve stimulation reduces neuropeptide Y levels through a muscarinic receptor-mediated mechanism. Crucially, blockade of presynaptic Y2-receptors was shown to further enhance these vagal effects, leading to a reduction in neuropeptide Y. This discovery elucidates a novel therapeutic target to modulate autonomic balance and potentially mitigate ventricular arrhythmia risk.
Article 3: Blood Pressure 15 to 90 Days After a Hypertensive Disorder of Pregnancy and Later Hypertension.
Journal: Hypertension (Dallas, Tex. : 1979)
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41048027
Summary: This retrospective cohort study investigated the association between postpartum blood pressure and the development of later hypertension following a hypertensive disorder of pregnancy. Researchers identified that blood pressure measurements taken 15 to 90 days after delivery are significantly associated with incident hypertension in women without pre-existing conditions. This finding emphasizes the critical importance of timely blood pressure monitoring during the early postpartum period for cardiovascular disease prevention strategies.
Article 4: Adaptation to Elevated Mitochondrial Calcium Is Distinct in the Left and Right Ventricles.
Journal: Circulation research
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41054844
Summary: This study explored the role of mitochondrial calcium in cardiomyocyte function, specifically focusing on the mitochondrial calcium uniporter complex and its subunit M.I.C.U.1, which regulates mitochondrial calcium uptake. Researchers discovered that the left and right ventricles exhibit distinct adaptive mechanisms to elevated mitochondrial calcium levels. This fundamental difference in ventricular calcium handling provides critical insights into the pathophysiology of heart failure and may inform ventricle-specific therapeutic strategies.
Article 5: Closed-Loop Vagus Nerve Stimulation Delivered With a Miniaturized System Produces Lasting Recovery in Individuals With Chronic Stroke.
Journal: Stroke
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41054846
Summary: This study introduces a miniaturized, closed-loop vagus nerve stimulation system designed to enhance recovery in individuals with chronic stroke. Building on the established benefits of vagus nerve stimulation combined with task-oriented training for upper limb recovery, this new system demonstrated significant and lasting improvements. The development offers a more refined and potentially less invasive approach compared to conventional devices, addressing a critical need in long-term stroke rehabilitation.
Transcript
Today’s date is October 08, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Chronotherapy as a novel strategy to limit anthracycline-induced cardiotoxicity. This review article proposes chronomodulated chemotherapy as a preventive strategy to mitigate anthracycline-induced cardiotoxicity. It highlights that adjusting anthracycline administration time to the body’s circadian rhythms may reduce the risk of heart failure in cancer patients and survivors. The concept is based on the significant role of circadian rhythms in cardiovascular physiology, suggesting a time-dependent variation in cardiac sensitivity to these chemotherapeutic agents.
Article number two. Sympathovagal crosstalk: Y2-receptor blockade enhances vagal effects which in turn Reduce NPY levels via muscarinic receptor activation. This study investigates the intricate sympathovagal crosstalk involved in ventricular arrhythmias, focusing on the role of neuropeptide Y. Researchers found that vagal nerve stimulation reduces neuropeptide Y levels through a muscarinic receptor-mediated mechanism. Crucially, blockade of presynaptic Y2-receptors was shown to further enhance these vagal effects, leading to a reduction in neuropeptide Y. This discovery elucidates a novel therapeutic target to modulate autonomic balance and potentially mitigate ventricular arrhythmia risk.
Article number three. Blood Pressure 15 to 90 Days After a Hypertensive Disorder of Pregnancy and Later Hypertension. This retrospective cohort study investigated the association between postpartum blood pressure and the development of later hypertension following a hypertensive disorder of pregnancy. Researchers identified that blood pressure measurements taken 15 to 90 days after delivery are significantly associated with incident hypertension in women without pre-existing conditions. This finding emphasizes the critical importance of timely blood pressure monitoring during the early postpartum period for cardiovascular disease prevention strategies.
Article number four. Adaptation to Elevated Mitochondrial Calcium Is Distinct in the Left and Right Ventricles. This study explored the role of mitochondrial calcium in cardiomyocyte function, specifically focusing on the mitochondrial calcium uniporter complex and its subunit M.I.C.U.1, which regulates mitochondrial calcium uptake. Researchers discovered that the left and right ventricles exhibit distinct adaptive mechanisms to elevated mitochondrial calcium levels. This fundamental difference in ventricular calcium handling provides critical insights into the pathophysiology of heart failure and may inform ventricle-specific therapeutic strategies.
Article number five. Closed-Loop Vagus Nerve Stimulation Delivered With a Miniaturized System Produces Lasting Recovery in Individuals With Chronic Stroke. This study introduces a miniaturized, closed-loop vagus nerve stimulation system designed to enhance recovery in individuals with chronic stroke. Building on the established benefits of vagus nerve stimulation combined with task-oriented training for upper limb recovery, this new system demonstrated significant and lasting improvements. The development offers a more refined and potentially less invasive approach compared to conventional devices, addressing a critical need in long-term stroke rehabilitation.
Thank you for listening. Don’t forget to subscribe.
Keywords
Ventricular arrhythmias, blood pressure monitoring, sympathoexcitation, cardiomyocyte function, M.I.C.U.1, Anthracycline cardiotoxicity, heart failure, muscarinic receptors, vagal nerve stimulation, postpartum hypertension, chronic stroke, chronotherapy, upper limb recovery, circadian rhythms, chemotherapy, Mitochondrial calcium, Vagus nerve stimulation, cardiovascular disease prevention, left ventricle, Y2-receptor blockade, neurorehabilitation, neuropeptide Y, incident hypertension, right ventricle, Hypertensive disorder of pregnancy, miniaturized device.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Y2-Receptor Blockade Quells Ventricular Arrhythmias. 10/08/25 first appeared on Cardiology Today.
Article Links:
Article 1: Chronotherapy as a novel strategy to limit anthracycline-induced cardiotoxicity. (Cardiovascular research)
Article 2: Sympathovagal crosstalk: Y2-receptor blockade enhances vagal effects which in turn Reduce NPY levels via muscarinic receptor activation. (Cardiovascular research)
Article 3: Blood Pressure 15 to 90 Days After a Hypertensive Disorder of Pregnancy and Later Hypertension. (Hypertension (Dallas, Tex. : 1979))
Article 4: Adaptation to Elevated Mitochondrial Calcium Is Distinct in the Left and Right Ventricles. (Circulation research)
Article 5: Closed-Loop Vagus Nerve Stimulation Delivered With a Miniaturized System Produces Lasting Recovery in Individuals With Chronic Stroke. (Stroke)
Full episode page: https://podcast.explainheart.com/podcast/y2-receptor-blockade-quells-ventricular-arrhythmias-10-08-25/
Featured Articles
Article 1: Chronotherapy as a novel strategy to limit anthracycline-induced cardiotoxicity.
Journal: Cardiovascular research
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41052913
Summary: This review article proposes chronomodulated chemotherapy as a preventive strategy to mitigate anthracycline-induced cardiotoxicity. It highlights that adjusting anthracycline administration time to the body’s circadian rhythms may reduce the risk of heart failure in cancer patients and survivors. The concept is based on the significant role of circadian rhythms in cardiovascular physiology, suggesting a time-dependent variation in cardiac sensitivity to these chemotherapeutic agents.
Article 2: Sympathovagal crosstalk: Y2-receptor blockade enhances vagal effects which in turn Reduce NPY levels via muscarinic receptor activation.
Journal: Cardiovascular research
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41052902
Summary: This study investigates the intricate sympathovagal crosstalk involved in ventricular arrhythmias, focusing on the role of neuropeptide Y. Researchers found that vagal nerve stimulation reduces neuropeptide Y levels through a muscarinic receptor-mediated mechanism. Crucially, blockade of presynaptic Y2-receptors was shown to further enhance these vagal effects, leading to a reduction in neuropeptide Y. This discovery elucidates a novel therapeutic target to modulate autonomic balance and potentially mitigate ventricular arrhythmia risk.
Article 3: Blood Pressure 15 to 90 Days After a Hypertensive Disorder of Pregnancy and Later Hypertension.
Journal: Hypertension (Dallas, Tex. : 1979)
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41048027
Summary: This retrospective cohort study investigated the association between postpartum blood pressure and the development of later hypertension following a hypertensive disorder of pregnancy. Researchers identified that blood pressure measurements taken 15 to 90 days after delivery are significantly associated with incident hypertension in women without pre-existing conditions. This finding emphasizes the critical importance of timely blood pressure monitoring during the early postpartum period for cardiovascular disease prevention strategies.
Article 4: Adaptation to Elevated Mitochondrial Calcium Is Distinct in the Left and Right Ventricles.
Journal: Circulation research
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41054844
Summary: This study explored the role of mitochondrial calcium in cardiomyocyte function, specifically focusing on the mitochondrial calcium uniporter complex and its subunit M.I.C.U.1, which regulates mitochondrial calcium uptake. Researchers discovered that the left and right ventricles exhibit distinct adaptive mechanisms to elevated mitochondrial calcium levels. This fundamental difference in ventricular calcium handling provides critical insights into the pathophysiology of heart failure and may inform ventricle-specific therapeutic strategies.
Article 5: Closed-Loop Vagus Nerve Stimulation Delivered With a Miniaturized System Produces Lasting Recovery in Individuals With Chronic Stroke.
Journal: Stroke
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41054846
Summary: This study introduces a miniaturized, closed-loop vagus nerve stimulation system designed to enhance recovery in individuals with chronic stroke. Building on the established benefits of vagus nerve stimulation combined with task-oriented training for upper limb recovery, this new system demonstrated significant and lasting improvements. The development offers a more refined and potentially less invasive approach compared to conventional devices, addressing a critical need in long-term stroke rehabilitation.
Transcript
Today’s date is October 08, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Chronotherapy as a novel strategy to limit anthracycline-induced cardiotoxicity. This review article proposes chronomodulated chemotherapy as a preventive strategy to mitigate anthracycline-induced cardiotoxicity. It highlights that adjusting anthracycline administration time to the body’s circadian rhythms may reduce the risk of heart failure in cancer patients and survivors. The concept is based on the significant role of circadian rhythms in cardiovascular physiology, suggesting a time-dependent variation in cardiac sensitivity to these chemotherapeutic agents.
Article number two. Sympathovagal crosstalk: Y2-receptor blockade enhances vagal effects which in turn Reduce NPY levels via muscarinic receptor activation. This study investigates the intricate sympathovagal crosstalk involved in ventricular arrhythmias, focusing on the role of neuropeptide Y. Researchers found that vagal nerve stimulation reduces neuropeptide Y levels through a muscarinic receptor-mediated mechanism. Crucially, blockade of presynaptic Y2-receptors was shown to further enhance these vagal effects, leading to a reduction in neuropeptide Y. This discovery elucidates a novel therapeutic target to modulate autonomic balance and potentially mitigate ventricular arrhythmia risk.
Article number three. Blood Pressure 15 to 90 Days After a Hypertensive Disorder of Pregnancy and Later Hypertension. This retrospective cohort study investigated the association between postpartum blood pressure and the development of later hypertension following a hypertensive disorder of pregnancy. Researchers identified that blood pressure measurements taken 15 to 90 days after delivery are significantly associated with incident hypertension in women without pre-existing conditions. This finding emphasizes the critical importance of timely blood pressure monitoring during the early postpartum period for cardiovascular disease prevention strategies.
Article number four. Adaptation to Elevated Mitochondrial Calcium Is Distinct in the Left and Right Ventricles. This study explored the role of mitochondrial calcium in cardiomyocyte function, specifically focusing on the mitochondrial calcium uniporter complex and its subunit M.I.C.U.1, which regulates mitochondrial calcium uptake. Researchers discovered that the left and right ventricles exhibit distinct adaptive mechanisms to elevated mitochondrial calcium levels. This fundamental difference in ventricular calcium handling provides critical insights into the pathophysiology of heart failure and may inform ventricle-specific therapeutic strategies.
Article number five. Closed-Loop Vagus Nerve Stimulation Delivered With a Miniaturized System Produces Lasting Recovery in Individuals With Chronic Stroke. This study introduces a miniaturized, closed-loop vagus nerve stimulation system designed to enhance recovery in individuals with chronic stroke. Building on the established benefits of vagus nerve stimulation combined with task-oriented training for upper limb recovery, this new system demonstrated significant and lasting improvements. The development offers a more refined and potentially less invasive approach compared to conventional devices, addressing a critical need in long-term stroke rehabilitation.
Thank you for listening. Don’t forget to subscribe.
Keywords
Ventricular arrhythmias, blood pressure monitoring, sympathoexcitation, cardiomyocyte function, M.I.C.U.1, Anthracycline cardiotoxicity, heart failure, muscarinic receptors, vagal nerve stimulation, postpartum hypertension, chronic stroke, chronotherapy, upper limb recovery, circadian rhythms, chemotherapy, Mitochondrial calcium, Vagus nerve stimulation, cardiovascular disease prevention, left ventricle, Y2-receptor blockade, neurorehabilitation, neuropeptide Y, incident hypertension, right ventricle, Hypertensive disorder of pregnancy, miniaturized device.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Y2-Receptor Blockade Quells Ventricular Arrhythmias. 10/08/25 first appeared on Cardiology Today.
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