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Listen "Radiation Safe for Leadless Pacemakers 10/04/25"
Episode Synopsis
Welcome to Cardiology Today – Recorded October 04, 2025. This episode summarizes 5 key cardiology studies on topics like L.R.P.5. and W.N.T. signaling. Key takeaway: Radiation Safe for Leadless Pacemakers.
Article Links:
Article 1: LRP5, a WNT signalling pathway receptor, and platelet activation. (European heart journal)
Article 2: Taurochenodeoxycholic acid alleviates obesity-induced endothelial dysfunction. (European heart journal)
Article 3: Role of routine surveillance stress testing in patients with or without imaging-guided or physiology-guided PCI. (Heart (British Cardiac Society))
Article 4: Ventricular Repolarisation is Improved by His Resynchronisation Therapy but not Biventricular Pacing. (Heart rhythm)
Article 5: Leadless Pacemakers Are Unaffected by External Beam Radiation in a Phantom Model. (Heart rhythm)
Full episode page: https://podcast.explainheart.com/podcast/radiation-safe-for-leadless-pacemakers-10-04-25/
Featured Articles
Article 1: LRP5, a WNT signalling pathway receptor, and platelet activation.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41042971
Summary: This study rigorously examined the role of L.R.P.5., a W.N.T. signaling pathway receptor, in regulating platelet function and hemostasis. Researchers utilized human platelets and L.R.P.5.-deficient murine platelets, challenging them with various agonists and inhibitors. The investigation revealed specific mechanisms by which L.R.P.5. influences platelet aggregation and activation pathways. These findings delineate L.R.P.5.’s critical involvement in thrombogenesis, suggesting it as a potential novel target for antiplatelet therapies.
Article 2: Taurochenodeoxycholic acid alleviates obesity-induced endothelial dysfunction.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41042950
Summary: This study investigated the heterogeneity of endothelial dysfunction in non-hypertensive obese individuals and sought to identify predictive and therapeutic serum metabolites. Utilizing wire myography, researchers confirmed that taurochenodeoxycholic acid, a specific bile acid, effectively alleviates obesity-induced endothelial dysfunction. This breakthrough suggests taurochenodeoxycholic acid could serve as a novel therapeutic target for preventing or treating cardiovascular disease in obese patients.
Article 3: Role of routine surveillance stress testing in patients with or without imaging-guided or physiology-guided PCI.
Journal: Heart (British Cardiac Society)
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41043864
Summary: The P.R.O.M.I.S.E. P.C.I. randomized trial, involving 1706 high-risk patients, compared the clinical utility of routine surveillance stress testing versus a symptom-oriented strategy after imaging-guided or physiology-guided percutaneous coronary intervention. The study aimed to definitively establish whether routine stress testing provides additional clinical benefit in this population. While the abstract does not detail the specific outcomes, the comprehensive trial results defined the optimal follow-up approach for enhancing post-P.C.I. patient management.
Article 4: Ventricular Repolarisation is Improved by His Resynchronisation Therapy but not Biventricular Pacing.
Journal: Heart rhythm
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41043630
Summary: This study directly compared His-bundle pacing cardiac resynchronization therapy with biventricular pacing cardiac resynchronization therapy for their effects on ventricular repolarization in patients with left bundle branch block. The pivotal finding was that His-bundle pacing cardiac resynchronization therapy significantly improved ventricular repolarization, while biventricular pacing did not confer this benefit. This suggests His-bundle pacing offers a superior physiological approach to cardiac resynchronization, potentially reducing ventricular arrhythmia risk.
Article 5: Leadless Pacemakers Are Unaffected by External Beam Radiation in a Phantom Model.
Journal: Heart rhythm
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41043629
Summary: This phantom model study assessed the impact of external beam radiation on leadless pacemakers, specifically the Medtronic Micra V.R., using advanced Varian TrueBeam and Ethos systems across various dose rates and flattening filter-free radiation modes. The study conclusively demonstrated that leadless pacemakers remain unaffected by radiation exposure. This crucial finding provides reassuring evidence for managing cancer patients with leadless pacemakers requiring radiation therapy, potentially simplifying treatment protocols.
Transcript
Today’s date is October 04, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. LRP5, a WNT signalling pathway receptor, and platelet activation. This study rigorously examined the role of L.R.P.5., a W.N.T. signaling pathway receptor, in regulating platelet function and hemostasis. Researchers utilized human platelets and L.R.P.5.-deficient murine platelets, challenging them with various agonists and inhibitors. The investigation revealed specific mechanisms by which L.R.P.5. influences platelet aggregation and activation pathways. These findings delineate L.R.P.5.’s critical involvement in thrombogenesis, suggesting it as a potential novel target for antiplatelet therapies.
Article number two. Taurochenodeoxycholic acid alleviates obesity-induced endothelial dysfunction. This study investigated the heterogeneity of endothelial dysfunction in non-hypertensive obese individuals and sought to identify predictive and therapeutic serum metabolites. Utilizing wire myography, researchers confirmed that taurochenodeoxycholic acid, a specific bile acid, effectively alleviates obesity-induced endothelial dysfunction. This breakthrough suggests taurochenodeoxycholic acid could serve as a novel therapeutic target for preventing or treating cardiovascular disease in obese patients.
Article number three. Role of routine surveillance stress testing in patients with or without imaging-guided or physiology-guided P.C.I. The P.R.O.M.I.S.E. P.C.I. randomized trial, involving 1706 high-risk patients, compared the clinical utility of routine surveillance stress testing versus a symptom-oriented strategy after imaging-guided or physiology-guided percutaneous coronary intervention. The study aimed to definitively establish whether routine stress testing provides additional clinical benefit in this population. While the abstract does not detail the specific outcomes, the comprehensive trial results defined the optimal follow-up approach for enhancing post-P.C.I. patient management.
Article number four. Ventricular Repolarisation is Improved by His Resynchronisation Therapy but not Biventricular Pacing. This study directly compared His-bundle pacing cardiac resynchronization therapy with biventricular pacing cardiac resynchronization therapy for their effects on ventricular repolarization in patients with left bundle branch block. The pivotal finding was that His-bundle pacing cardiac resynchronization therapy significantly improved ventricular repolarization, while biventricular pacing did not confer this benefit. This suggests His-bundle pacing offers a superior physiological approach to cardiac resynchronization, potentially reducing ventricular arrhythmia risk.
Article number five. Leadless Pacemakers Are Unaffected by External Beam Radiation in a Phantom Model. This phantom model study assessed the impact of external beam radiation on leadless pacemakers, specifically the Medtronic Micra V.R., using advanced Varian TrueBeam and Ethos systems across various dose rates and flattening filter-free radiation modes. The study conclusively demonstrated that leadless pacemakers remain unaffected by radiation exposure. This crucial finding provides reassuring evidence for managing cancer patients with leadless pacemakers requiring radiation therapy, potentially simplifying treatment protocols.
Thank you for listening. Don’t forget to subscribe.
Keywords
L.R.P.5., W.N.T. signaling, cardiovascular disease, cardiac resynchronization therapy, Micra V.R., biventricular pacing, percutaneous coronary intervention, serum metabolites, phantom model, fractional flow reserve, antiplatelet therapy, ventricular repolarization, leadless pacemaker, radiation therapy, hemostasis, imaging-guided P.C.I., His-bundle pacing, left bundle branch block, taurochenodeoxycholic acid, platelet activation, stress testing, obesity, external beam radiation, endothelial dysfunction, follow-up strategy.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Radiation Safe for Leadless Pacemakers 10/04/25 first appeared on Cardiology Today.
Article Links:
Article 1: LRP5, a WNT signalling pathway receptor, and platelet activation. (European heart journal)
Article 2: Taurochenodeoxycholic acid alleviates obesity-induced endothelial dysfunction. (European heart journal)
Article 3: Role of routine surveillance stress testing in patients with or without imaging-guided or physiology-guided PCI. (Heart (British Cardiac Society))
Article 4: Ventricular Repolarisation is Improved by His Resynchronisation Therapy but not Biventricular Pacing. (Heart rhythm)
Article 5: Leadless Pacemakers Are Unaffected by External Beam Radiation in a Phantom Model. (Heart rhythm)
Full episode page: https://podcast.explainheart.com/podcast/radiation-safe-for-leadless-pacemakers-10-04-25/
Featured Articles
Article 1: LRP5, a WNT signalling pathway receptor, and platelet activation.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41042971
Summary: This study rigorously examined the role of L.R.P.5., a W.N.T. signaling pathway receptor, in regulating platelet function and hemostasis. Researchers utilized human platelets and L.R.P.5.-deficient murine platelets, challenging them with various agonists and inhibitors. The investigation revealed specific mechanisms by which L.R.P.5. influences platelet aggregation and activation pathways. These findings delineate L.R.P.5.’s critical involvement in thrombogenesis, suggesting it as a potential novel target for antiplatelet therapies.
Article 2: Taurochenodeoxycholic acid alleviates obesity-induced endothelial dysfunction.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41042950
Summary: This study investigated the heterogeneity of endothelial dysfunction in non-hypertensive obese individuals and sought to identify predictive and therapeutic serum metabolites. Utilizing wire myography, researchers confirmed that taurochenodeoxycholic acid, a specific bile acid, effectively alleviates obesity-induced endothelial dysfunction. This breakthrough suggests taurochenodeoxycholic acid could serve as a novel therapeutic target for preventing or treating cardiovascular disease in obese patients.
Article 3: Role of routine surveillance stress testing in patients with or without imaging-guided or physiology-guided PCI.
Journal: Heart (British Cardiac Society)
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41043864
Summary: The P.R.O.M.I.S.E. P.C.I. randomized trial, involving 1706 high-risk patients, compared the clinical utility of routine surveillance stress testing versus a symptom-oriented strategy after imaging-guided or physiology-guided percutaneous coronary intervention. The study aimed to definitively establish whether routine stress testing provides additional clinical benefit in this population. While the abstract does not detail the specific outcomes, the comprehensive trial results defined the optimal follow-up approach for enhancing post-P.C.I. patient management.
Article 4: Ventricular Repolarisation is Improved by His Resynchronisation Therapy but not Biventricular Pacing.
Journal: Heart rhythm
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41043630
Summary: This study directly compared His-bundle pacing cardiac resynchronization therapy with biventricular pacing cardiac resynchronization therapy for their effects on ventricular repolarization in patients with left bundle branch block. The pivotal finding was that His-bundle pacing cardiac resynchronization therapy significantly improved ventricular repolarization, while biventricular pacing did not confer this benefit. This suggests His-bundle pacing offers a superior physiological approach to cardiac resynchronization, potentially reducing ventricular arrhythmia risk.
Article 5: Leadless Pacemakers Are Unaffected by External Beam Radiation in a Phantom Model.
Journal: Heart rhythm
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41043629
Summary: This phantom model study assessed the impact of external beam radiation on leadless pacemakers, specifically the Medtronic Micra V.R., using advanced Varian TrueBeam and Ethos systems across various dose rates and flattening filter-free radiation modes. The study conclusively demonstrated that leadless pacemakers remain unaffected by radiation exposure. This crucial finding provides reassuring evidence for managing cancer patients with leadless pacemakers requiring radiation therapy, potentially simplifying treatment protocols.
Transcript
Today’s date is October 04, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. LRP5, a WNT signalling pathway receptor, and platelet activation. This study rigorously examined the role of L.R.P.5., a W.N.T. signaling pathway receptor, in regulating platelet function and hemostasis. Researchers utilized human platelets and L.R.P.5.-deficient murine platelets, challenging them with various agonists and inhibitors. The investigation revealed specific mechanisms by which L.R.P.5. influences platelet aggregation and activation pathways. These findings delineate L.R.P.5.’s critical involvement in thrombogenesis, suggesting it as a potential novel target for antiplatelet therapies.
Article number two. Taurochenodeoxycholic acid alleviates obesity-induced endothelial dysfunction. This study investigated the heterogeneity of endothelial dysfunction in non-hypertensive obese individuals and sought to identify predictive and therapeutic serum metabolites. Utilizing wire myography, researchers confirmed that taurochenodeoxycholic acid, a specific bile acid, effectively alleviates obesity-induced endothelial dysfunction. This breakthrough suggests taurochenodeoxycholic acid could serve as a novel therapeutic target for preventing or treating cardiovascular disease in obese patients.
Article number three. Role of routine surveillance stress testing in patients with or without imaging-guided or physiology-guided P.C.I. The P.R.O.M.I.S.E. P.C.I. randomized trial, involving 1706 high-risk patients, compared the clinical utility of routine surveillance stress testing versus a symptom-oriented strategy after imaging-guided or physiology-guided percutaneous coronary intervention. The study aimed to definitively establish whether routine stress testing provides additional clinical benefit in this population. While the abstract does not detail the specific outcomes, the comprehensive trial results defined the optimal follow-up approach for enhancing post-P.C.I. patient management.
Article number four. Ventricular Repolarisation is Improved by His Resynchronisation Therapy but not Biventricular Pacing. This study directly compared His-bundle pacing cardiac resynchronization therapy with biventricular pacing cardiac resynchronization therapy for their effects on ventricular repolarization in patients with left bundle branch block. The pivotal finding was that His-bundle pacing cardiac resynchronization therapy significantly improved ventricular repolarization, while biventricular pacing did not confer this benefit. This suggests His-bundle pacing offers a superior physiological approach to cardiac resynchronization, potentially reducing ventricular arrhythmia risk.
Article number five. Leadless Pacemakers Are Unaffected by External Beam Radiation in a Phantom Model. This phantom model study assessed the impact of external beam radiation on leadless pacemakers, specifically the Medtronic Micra V.R., using advanced Varian TrueBeam and Ethos systems across various dose rates and flattening filter-free radiation modes. The study conclusively demonstrated that leadless pacemakers remain unaffected by radiation exposure. This crucial finding provides reassuring evidence for managing cancer patients with leadless pacemakers requiring radiation therapy, potentially simplifying treatment protocols.
Thank you for listening. Don’t forget to subscribe.
Keywords
L.R.P.5., W.N.T. signaling, cardiovascular disease, cardiac resynchronization therapy, Micra V.R., biventricular pacing, percutaneous coronary intervention, serum metabolites, phantom model, fractional flow reserve, antiplatelet therapy, ventricular repolarization, leadless pacemaker, radiation therapy, hemostasis, imaging-guided P.C.I., His-bundle pacing, left bundle branch block, taurochenodeoxycholic acid, platelet activation, stress testing, obesity, external beam radiation, endothelial dysfunction, follow-up strategy.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Radiation Safe for Leadless Pacemakers 10/04/25 first appeared on Cardiology Today.
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