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Listen "Phenotypic Age Predicts Sudden Cardiac Arrest. 11/23/25"
Episode Synopsis
Welcome to Cardiology Today – Recorded November 23, 2025. This episode summarizes 5 key cardiology studies on topics like low-density lipoprotein cholesterol and ventricular arrhythmias. Key takeaway: Phenotypic Age Predicts Sudden Cardiac Arrest..
Article Links:
Article 1: Lipoprotein(a) and recurrent atherosclerotic cardiovascular events: the US Family Heart Database. (European heart journal)
Article 2: Efficacy and Safety of Fetal Magnetocardiography for Detecting Fetal Cardiac Magnetic Signals: A Two-Center, Single-Arm, Prospective Clinical Trial (FAMILY). (Heart rhythm)
Article 3: Association of phenotypic age acceleration with risk of sudden cardiac arrest: evidence from a large retrospective cohort. (Heart rhythm)
Article 4: Ablation of Idiopathic Ventricular Arrhythmias from the Right Ventricular Apex. (Heart rhythm)
Article 5: Equity in Heart Failure Care: Examining the Area-based Marginalization Status of Patients in an RPM Program. (The Canadian journal of cardiology)
Full episode page: https://podcast.explainheart.com/podcast/phenotypic-age-predicts-sudden-cardiac-arrest-11-23-25/
Featured Articles
Article 1: Lipoprotein(a) and recurrent atherosclerotic cardiovascular events: the US Family Heart Database.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40331569
Summary: Higher levels of lipoprotein(a) are established as increasing atherosclerotic cardiovascular disease risk in otherwise healthy individuals, irrespective of sex and race or ethnicity. This study analyzed 273770 individuals from a U. S. medical claims database with diagnosed atherosclerotic cardiovascular disease and measured lipoprotein(a) levels. The research confirmed the clinical significance of lipoprotein(a) as a crucial driver for recurrent atherosclerotic cardiovascular events. It also assessed the influence of low-density lipoprotein cholesterol-lowering therapy on this relationship in patients with established disease.
Article 2: Efficacy and Safety of Fetal Magnetocardiography for Detecting Fetal Cardiac Magnetic Signals: A Two-Center, Single-Arm, Prospective Clinical Trial (FAMILY).
Journal: Heart rhythm
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41274325
Summary: Fetal magnetocardiography provides precise, non-invasive detection of fetal cardiac electrical activity, which conventional echocardiography cannot record. The F. A. M. I. L. Y. clinical trial evaluated the efficacy and safety of fetal magnetocardiography for detecting fetal cardiac magnetic signals. This two-center, single-arm, prospective study confirmed fetal magnetocardiography’s capability for accurate detection of fetal cardiac time intervals, essential for diagnosing arrhythmias. The research established fetal magnetocardiography as a vital tool by directly comparing its performance with fetal electrocardiography.
Article 3: Association of phenotypic age acceleration with risk of sudden cardiac arrest: evidence from a large retrospective cohort.
Journal: Heart rhythm
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41274324
Summary: This large retrospective cohort analysis of 360663 U. K. Biobank participants found a significant association between phenotypic age acceleration and the risk of incident sudden cardiac arrest. The study established phenotypic age acceleration as a convenient proxy for biological aging and a substantial contributor to cardiovascular disease development. Researchers demonstrated that individuals with higher phenotypic age acceleration face an increased risk of sudden cardiac arrest. This provides crucial evidence for incorporating biological aging markers into risk assessment for sudden cardiac arrest.
Article 4: Ablation of Idiopathic Ventricular Arrhythmias from the Right Ventricular Apex.
Journal: Heart rhythm
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41274323
Summary: This study defined the electrocardiogram characteristics and ablation outcomes for idiopathic ventricular arrhythmias originating from the right ventricular apex. Researchers conducted a retrospective analysis of patients undergoing catheter ablation for these arrhythmias across three centers. The study provided crucial data distinguishing right ventricular apical ventricular arrhythmias, including premature ventricular contractions and ventricular tachycardia, from other right ventricular sources. The findings contribute to improved diagnostic and therapeutic strategies for this specific and less-understood subset of ventricular arrhythmias.
Article 5: Equity in Heart Failure Care: Examining the Area-based Marginalization Status of Patients in an RPM Program.
Journal: The Canadian journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41274562
Summary: This study found that a remote patient management program for heart failure demonstrated equitable accessibility across various area-based marginalization statuses. The program’s design, which provides necessary equipment, employs minimal exclusion criteria, and is compatible with both Android and I. Phone devices, contributed to this equitable access. This research indicates that carefully structured remote patient management programs can effectively reach diverse heart failure patient populations. The findings suggest a model for inclusive and accessible heart failure care delivery.
Transcript
Today’s date is November 23, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Lipoprotein(a) and recurrent atherosclerotic cardiovascular events: the US Family Heart Database. Higher levels of lipoprotein(a) are established as increasing atherosclerotic cardiovascular disease risk in otherwise healthy individuals, irrespective of sex and race or ethnicity. This study analyzed 273770 individuals from a U. S. medical claims database with diagnosed atherosclerotic cardiovascular disease and measured lipoprotein(a) levels. The research confirmed the clinical significance of lipoprotein(a) as a crucial driver for recurrent atherosclerotic cardiovascular events. It also assessed the influence of low-density lipoprotein cholesterol-lowering therapy on this relationship in patients with established disease.
Article number two. Efficacy and Safety of Fetal Magnetocardiography for Detecting Fetal Cardiac Magnetic Signals: A Two-Center, Single-Arm, Prospective Clinical Trial (FAMILY). Fetal magnetocardiography provides precise, non-invasive detection of fetal cardiac electrical activity, which conventional echocardiography cannot record. The F. A. M. I. L. Y. clinical trial evaluated the efficacy and safety of fetal magnetocardiography for detecting fetal cardiac magnetic signals. This two-center, single-arm, prospective study confirmed fetal magnetocardiography’s capability for accurate detection of fetal cardiac time intervals, essential for diagnosing arrhythmias. The research established fetal magnetocardiography as a vital tool by directly comparing its performance with fetal electrocardiography.
Article number three. Association of phenotypic age acceleration with risk of sudden cardiac arrest: evidence from a large retrospective cohort. This large retrospective cohort analysis of 360663 U. K. Biobank participants found a significant association between phenotypic age acceleration and the risk of incident sudden cardiac arrest. The study established phenotypic age acceleration as a convenient proxy for biological aging and a substantial contributor to cardiovascular disease development. Researchers demonstrated that individuals with higher phenotypic age acceleration face an increased risk of sudden cardiac arrest. This provides crucial evidence for incorporating biological aging markers into risk assessment for sudden cardiac arrest.
Article number four. Ablation of Idiopathic Ventricular Arrhythmias from the Right Ventricular Apex. This study defined the electrocardiogram characteristics and ablation outcomes for idiopathic ventricular arrhythmias originating from the right ventricular apex. Researchers conducted a retrospective analysis of patients undergoing catheter ablation for these arrhythmias across three centers. The study provided crucial data distinguishing right ventricular apical ventricular arrhythmias, including premature ventricular contractions and ventricular tachycardia, from other right ventricular sources. The findings contribute to improved diagnostic and therapeutic strategies for this specific and less-understood subset of ventricular arrhythmias.
Article number five. Equity in Heart Failure Care: Examining the Area-based Marginalization Status of Patients in an RPM Program. This study found that a remote patient management program for heart failure demonstrated equitable accessibility across various area-based marginalization statuses. The program’s design, which provides necessary equipment, employs minimal exclusion criteria, and is compatible with both Android and I. Phone devices, contributed to this equitable access. This research indicates that carefully structured remote patient management programs can effectively reach diverse heart failure patient populations. The findings suggest a model for inclusive and accessible heart failure care delivery.
Thank you for listening. Don’t forget to subscribe.
Keywords
low-density lipoprotein cholesterol, ventricular arrhythmias, cardiovascular disease, ventricular tachycardia, recurrent events, remote patient management, right ventricular apex, secondary prevention, fetal electrocardiography, premature ventricular contractions, lipoprotein(a), sudden cardiac arrest, catheter ablation, health equity, marginalization status, fetal cardiac signals, access to care, risk prediction, heart failure, fetal arrhythmias, phenotypic age acceleration, non-invasive detection, fetal magnetocardiography, atherosclerotic cardiovascular disease, biological aging.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Phenotypic Age Predicts Sudden Cardiac Arrest. 11/23/25 first appeared on Cardiology Today.
Article Links:
Article 1: Lipoprotein(a) and recurrent atherosclerotic cardiovascular events: the US Family Heart Database. (European heart journal)
Article 2: Efficacy and Safety of Fetal Magnetocardiography for Detecting Fetal Cardiac Magnetic Signals: A Two-Center, Single-Arm, Prospective Clinical Trial (FAMILY). (Heart rhythm)
Article 3: Association of phenotypic age acceleration with risk of sudden cardiac arrest: evidence from a large retrospective cohort. (Heart rhythm)
Article 4: Ablation of Idiopathic Ventricular Arrhythmias from the Right Ventricular Apex. (Heart rhythm)
Article 5: Equity in Heart Failure Care: Examining the Area-based Marginalization Status of Patients in an RPM Program. (The Canadian journal of cardiology)
Full episode page: https://podcast.explainheart.com/podcast/phenotypic-age-predicts-sudden-cardiac-arrest-11-23-25/
Featured Articles
Article 1: Lipoprotein(a) and recurrent atherosclerotic cardiovascular events: the US Family Heart Database.
Journal: European heart journal
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40331569
Summary: Higher levels of lipoprotein(a) are established as increasing atherosclerotic cardiovascular disease risk in otherwise healthy individuals, irrespective of sex and race or ethnicity. This study analyzed 273770 individuals from a U. S. medical claims database with diagnosed atherosclerotic cardiovascular disease and measured lipoprotein(a) levels. The research confirmed the clinical significance of lipoprotein(a) as a crucial driver for recurrent atherosclerotic cardiovascular events. It also assessed the influence of low-density lipoprotein cholesterol-lowering therapy on this relationship in patients with established disease.
Article 2: Efficacy and Safety of Fetal Magnetocardiography for Detecting Fetal Cardiac Magnetic Signals: A Two-Center, Single-Arm, Prospective Clinical Trial (FAMILY).
Journal: Heart rhythm
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41274325
Summary: Fetal magnetocardiography provides precise, non-invasive detection of fetal cardiac electrical activity, which conventional echocardiography cannot record. The F. A. M. I. L. Y. clinical trial evaluated the efficacy and safety of fetal magnetocardiography for detecting fetal cardiac magnetic signals. This two-center, single-arm, prospective study confirmed fetal magnetocardiography’s capability for accurate detection of fetal cardiac time intervals, essential for diagnosing arrhythmias. The research established fetal magnetocardiography as a vital tool by directly comparing its performance with fetal electrocardiography.
Article 3: Association of phenotypic age acceleration with risk of sudden cardiac arrest: evidence from a large retrospective cohort.
Journal: Heart rhythm
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41274324
Summary: This large retrospective cohort analysis of 360663 U. K. Biobank participants found a significant association between phenotypic age acceleration and the risk of incident sudden cardiac arrest. The study established phenotypic age acceleration as a convenient proxy for biological aging and a substantial contributor to cardiovascular disease development. Researchers demonstrated that individuals with higher phenotypic age acceleration face an increased risk of sudden cardiac arrest. This provides crucial evidence for incorporating biological aging markers into risk assessment for sudden cardiac arrest.
Article 4: Ablation of Idiopathic Ventricular Arrhythmias from the Right Ventricular Apex.
Journal: Heart rhythm
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41274323
Summary: This study defined the electrocardiogram characteristics and ablation outcomes for idiopathic ventricular arrhythmias originating from the right ventricular apex. Researchers conducted a retrospective analysis of patients undergoing catheter ablation for these arrhythmias across three centers. The study provided crucial data distinguishing right ventricular apical ventricular arrhythmias, including premature ventricular contractions and ventricular tachycardia, from other right ventricular sources. The findings contribute to improved diagnostic and therapeutic strategies for this specific and less-understood subset of ventricular arrhythmias.
Article 5: Equity in Heart Failure Care: Examining the Area-based Marginalization Status of Patients in an RPM Program.
Journal: The Canadian journal of cardiology
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41274562
Summary: This study found that a remote patient management program for heart failure demonstrated equitable accessibility across various area-based marginalization statuses. The program’s design, which provides necessary equipment, employs minimal exclusion criteria, and is compatible with both Android and I. Phone devices, contributed to this equitable access. This research indicates that carefully structured remote patient management programs can effectively reach diverse heart failure patient populations. The findings suggest a model for inclusive and accessible heart failure care delivery.
Transcript
Today’s date is November 23, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Lipoprotein(a) and recurrent atherosclerotic cardiovascular events: the US Family Heart Database. Higher levels of lipoprotein(a) are established as increasing atherosclerotic cardiovascular disease risk in otherwise healthy individuals, irrespective of sex and race or ethnicity. This study analyzed 273770 individuals from a U. S. medical claims database with diagnosed atherosclerotic cardiovascular disease and measured lipoprotein(a) levels. The research confirmed the clinical significance of lipoprotein(a) as a crucial driver for recurrent atherosclerotic cardiovascular events. It also assessed the influence of low-density lipoprotein cholesterol-lowering therapy on this relationship in patients with established disease.
Article number two. Efficacy and Safety of Fetal Magnetocardiography for Detecting Fetal Cardiac Magnetic Signals: A Two-Center, Single-Arm, Prospective Clinical Trial (FAMILY). Fetal magnetocardiography provides precise, non-invasive detection of fetal cardiac electrical activity, which conventional echocardiography cannot record. The F. A. M. I. L. Y. clinical trial evaluated the efficacy and safety of fetal magnetocardiography for detecting fetal cardiac magnetic signals. This two-center, single-arm, prospective study confirmed fetal magnetocardiography’s capability for accurate detection of fetal cardiac time intervals, essential for diagnosing arrhythmias. The research established fetal magnetocardiography as a vital tool by directly comparing its performance with fetal electrocardiography.
Article number three. Association of phenotypic age acceleration with risk of sudden cardiac arrest: evidence from a large retrospective cohort. This large retrospective cohort analysis of 360663 U. K. Biobank participants found a significant association between phenotypic age acceleration and the risk of incident sudden cardiac arrest. The study established phenotypic age acceleration as a convenient proxy for biological aging and a substantial contributor to cardiovascular disease development. Researchers demonstrated that individuals with higher phenotypic age acceleration face an increased risk of sudden cardiac arrest. This provides crucial evidence for incorporating biological aging markers into risk assessment for sudden cardiac arrest.
Article number four. Ablation of Idiopathic Ventricular Arrhythmias from the Right Ventricular Apex. This study defined the electrocardiogram characteristics and ablation outcomes for idiopathic ventricular arrhythmias originating from the right ventricular apex. Researchers conducted a retrospective analysis of patients undergoing catheter ablation for these arrhythmias across three centers. The study provided crucial data distinguishing right ventricular apical ventricular arrhythmias, including premature ventricular contractions and ventricular tachycardia, from other right ventricular sources. The findings contribute to improved diagnostic and therapeutic strategies for this specific and less-understood subset of ventricular arrhythmias.
Article number five. Equity in Heart Failure Care: Examining the Area-based Marginalization Status of Patients in an RPM Program. This study found that a remote patient management program for heart failure demonstrated equitable accessibility across various area-based marginalization statuses. The program’s design, which provides necessary equipment, employs minimal exclusion criteria, and is compatible with both Android and I. Phone devices, contributed to this equitable access. This research indicates that carefully structured remote patient management programs can effectively reach diverse heart failure patient populations. The findings suggest a model for inclusive and accessible heart failure care delivery.
Thank you for listening. Don’t forget to subscribe.
Keywords
low-density lipoprotein cholesterol, ventricular arrhythmias, cardiovascular disease, ventricular tachycardia, recurrent events, remote patient management, right ventricular apex, secondary prevention, fetal electrocardiography, premature ventricular contractions, lipoprotein(a), sudden cardiac arrest, catheter ablation, health equity, marginalization status, fetal cardiac signals, access to care, risk prediction, heart failure, fetal arrhythmias, phenotypic age acceleration, non-invasive detection, fetal magnetocardiography, atherosclerotic cardiovascular disease, biological aging.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Phenotypic Age Predicts Sudden Cardiac Arrest. 11/23/25 first appeared on Cardiology Today.
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