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Listen "Osimertinib Arrhythmia: K.C.N.N.1 Link Found 10/03/25"
Episode Synopsis
Welcome to Cardiology Today – Recorded October 03, 2025. This episode summarizes 5 key cardiology studies on topics like gene-edited pigs and H.C.N.4. Key takeaway: Osimertinib Arrhythmia: K.C.N.N.1 Link Found.
Article Links:
Article 1: Characterizing the Immune Response in Pig-to-human Heart Xenografts Using a Multimodal Diagnostic System. (Circulation)
Article 2: Congestion and Low Cardiac Output Hemodynamic Phenotype Drives Outcomes in Overweight and Obese HFpEF. (JACC. Heart failure)
Article 3: Osimertinib induces prolongation of action potential duration via downregulation of KCNN1 expression: Exploring the potential mechanisms of arrhythmia. (Heart rhythm)
Article 4: miR-363-5p- and IL-34-mediated modulation of pacemaker channel, HCN4, on iPSC-CM: Translation into the human sinus node microenvironment. (Heart rhythm)
Article 5: Incidence and predictors of temporary pacemaker implantation-induced cardiac perforation. (Heart rhythm)
Full episode page: https://podcast.explainheart.com/podcast/osimertinib-arrhythmia-k-c-n-n-1-link-found-10-03-25/
Featured Articles
Article 1: Characterizing the Immune Response in Pig-to-human Heart Xenografts Using a Multimodal Diagnostic System.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41036838
Summary: Article number one. Characterizing the Immune Response in Pig-to-human Heart Xenografts Using a Multimodal Diagnostic System.
Article 2: Congestion and Low Cardiac Output Hemodynamic Phenotype Drives Outcomes in Overweight and Obese HFpEF.
Journal: JACC. Heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41037837
Summary: Article number two. Congestion and Low Cardiac Output Hemodynamic Phenotype Drives Outcomes in Overweight and Obese Heart Failure with Preserved Ejection Fraction.
Article 3: Osimertinib induces prolongation of action potential duration via downregulation of KCNN1 expression: Exploring the potential mechanisms of arrhythmia.
Journal: Heart rhythm
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40653133
Summary: Article number three. Osimertinib induces prolongation of action potential duration via downregulation of K.C.N.N.1 expression: Exploring the potential mechanisms of arrhythmia.
Article 4: miR-363-5p- and IL-34-mediated modulation of pacemaker channel, HCN4, on iPSC-CM: Translation into the human sinus node microenvironment.
Journal: Heart rhythm
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40645436
Summary: Article number four. microRNA-363-5p- and I.L.-34-mediated modulation of pacemaker channel, H.C.N.4, on induced pluripotent stem cell-derived cardiomyocytes: Translation into the human sinus node microenvironment.
Article 5: Incidence and predictors of temporary pacemaker implantation-induced cardiac perforation.
Journal: Heart rhythm
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40582687
Summary: Article number five. Incidence and predictors of temporary pacemaker implantation-induced cardiac perforation.
Transcript
Today’s date is October 03, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Characterizing the Immune Response in Pig-to-human Heart Xenografts Using a Multimodal Diagnostic System.
Article number two. Congestion and Low Cardiac Output Hemodynamic Phenotype Drives Outcomes in Overweight and Obese Heart Failure with Preserved Ejection Fraction.
Article number three. Osimertinib induces prolongation of action potential duration via downregulation of K.C.N.N.1 expression: Exploring the potential mechanisms of arrhythmia.
Article number four. microRNA-363-5p- and I.L.-34-mediated modulation of pacemaker channel, H.C.N.4, on induced pluripotent stem cell-derived cardiomyocytes: Translation into the human sinus node microenvironment.
Article number five. Incidence and predictors of temporary pacemaker implantation-induced cardiac perforation.
Thank you for listening. Don’t forget to subscribe.
Keywords
gene-edited pigs, H.C.N.4, epidermal growth factor receptor-tyrosine kinase inhibitor, induced pluripotent stem cell-derived cardiomyocytes, incidence, cardiotoxicity, congestion, heart rate modulation, Heart Failure with Preserved Ejection Fraction, echocardiographic imaging, pacing complications, cardiac tamponade, osimertinib, arrhythmia, sinus node, pig-to-human heart transplant, xenotransplantation, action potential duration, transvenous temporary pacing, multimodal phenotyping, xeno-immune response, obesity, cardiac perforation, low cardiac output, I.L.-34, K.C.N.N.1, microRNAs, hemodynamic phenotype, clinical outcomes.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Osimertinib Arrhythmia: K.C.N.N.1 Link Found 10/03/25 first appeared on Cardiology Today.
Article Links:
Article 1: Characterizing the Immune Response in Pig-to-human Heart Xenografts Using a Multimodal Diagnostic System. (Circulation)
Article 2: Congestion and Low Cardiac Output Hemodynamic Phenotype Drives Outcomes in Overweight and Obese HFpEF. (JACC. Heart failure)
Article 3: Osimertinib induces prolongation of action potential duration via downregulation of KCNN1 expression: Exploring the potential mechanisms of arrhythmia. (Heart rhythm)
Article 4: miR-363-5p- and IL-34-mediated modulation of pacemaker channel, HCN4, on iPSC-CM: Translation into the human sinus node microenvironment. (Heart rhythm)
Article 5: Incidence and predictors of temporary pacemaker implantation-induced cardiac perforation. (Heart rhythm)
Full episode page: https://podcast.explainheart.com/podcast/osimertinib-arrhythmia-k-c-n-n-1-link-found-10-03-25/
Featured Articles
Article 1: Characterizing the Immune Response in Pig-to-human Heart Xenografts Using a Multimodal Diagnostic System.
Journal: Circulation
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41036838
Summary: Article number one. Characterizing the Immune Response in Pig-to-human Heart Xenografts Using a Multimodal Diagnostic System.
Article 2: Congestion and Low Cardiac Output Hemodynamic Phenotype Drives Outcomes in Overweight and Obese HFpEF.
Journal: JACC. Heart failure
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/41037837
Summary: Article number two. Congestion and Low Cardiac Output Hemodynamic Phenotype Drives Outcomes in Overweight and Obese Heart Failure with Preserved Ejection Fraction.
Article 3: Osimertinib induces prolongation of action potential duration via downregulation of KCNN1 expression: Exploring the potential mechanisms of arrhythmia.
Journal: Heart rhythm
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40653133
Summary: Article number three. Osimertinib induces prolongation of action potential duration via downregulation of K.C.N.N.1 expression: Exploring the potential mechanisms of arrhythmia.
Article 4: miR-363-5p- and IL-34-mediated modulation of pacemaker channel, HCN4, on iPSC-CM: Translation into the human sinus node microenvironment.
Journal: Heart rhythm
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40645436
Summary: Article number four. microRNA-363-5p- and I.L.-34-mediated modulation of pacemaker channel, H.C.N.4, on induced pluripotent stem cell-derived cardiomyocytes: Translation into the human sinus node microenvironment.
Article 5: Incidence and predictors of temporary pacemaker implantation-induced cardiac perforation.
Journal: Heart rhythm
PubMed Link: https://pubmed.ncbi.nlm.nih.gov/40582687
Summary: Article number five. Incidence and predictors of temporary pacemaker implantation-induced cardiac perforation.
Transcript
Today’s date is October 03, 2025. Welcome to Cardiology Today. Here are the latest research findings.
Article number one. Characterizing the Immune Response in Pig-to-human Heart Xenografts Using a Multimodal Diagnostic System.
Article number two. Congestion and Low Cardiac Output Hemodynamic Phenotype Drives Outcomes in Overweight and Obese Heart Failure with Preserved Ejection Fraction.
Article number three. Osimertinib induces prolongation of action potential duration via downregulation of K.C.N.N.1 expression: Exploring the potential mechanisms of arrhythmia.
Article number four. microRNA-363-5p- and I.L.-34-mediated modulation of pacemaker channel, H.C.N.4, on induced pluripotent stem cell-derived cardiomyocytes: Translation into the human sinus node microenvironment.
Article number five. Incidence and predictors of temporary pacemaker implantation-induced cardiac perforation.
Thank you for listening. Don’t forget to subscribe.
Keywords
gene-edited pigs, H.C.N.4, epidermal growth factor receptor-tyrosine kinase inhibitor, induced pluripotent stem cell-derived cardiomyocytes, incidence, cardiotoxicity, congestion, heart rate modulation, Heart Failure with Preserved Ejection Fraction, echocardiographic imaging, pacing complications, cardiac tamponade, osimertinib, arrhythmia, sinus node, pig-to-human heart transplant, xenotransplantation, action potential duration, transvenous temporary pacing, multimodal phenotyping, xeno-immune response, obesity, cardiac perforation, low cardiac output, I.L.-34, K.C.N.N.1, microRNAs, hemodynamic phenotype, clinical outcomes.
About
Concise summaries of cardiovascular research for professionals.
Subscribe • Share • FollowThe post Osimertinib Arrhythmia: K.C.N.N.1 Link Found 10/03/25 first appeared on Cardiology Today.
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