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Listen "Senescence and Aging Relative to T lymphocytes may be linked to chemotherapy of testicular cancer and underlying cell cycle-CD transcriptional mutations."
Episode Synopsis
Dr Guerra continues his associative pathobiochemical dialectic concerning T lymphocytte differentaition and senescence
The Th and Tc populations following uptake and processing of an antigen by an APC such as a dendritic cell is presented either to the CD8 population in the context of MHC-I or to the CD4 subpopulation in the context of MHC-II generates a cascading set of cellular lymphoproliferative and differentiative steps initiated under the inductive influence of cytokines that ultimately determine effector functions.
Papers examined in this episode:
Nat Med. 2017 Jun; 23(6): 775–781
Cancer Genet Cytogenet. 1999 Mar;109(2):108-13.
BMC Cancer volume 20, Article number: 882 (2020)
The Th and Tc populations following uptake and processing of an antigen by an APC such as a dendritic cell is presented either to the CD8 population in the context of MHC-I or to the CD4 subpopulation in the context of MHC-II generates a cascading set of cellular lymphoproliferative and differentiative steps initiated under the inductive influence of cytokines that ultimately determine effector functions.
Papers examined in this episode:
Nat Med. 2017 Jun; 23(6): 775–781
Cancer Genet Cytogenet. 1999 Mar;109(2):108-13.
BMC Cancer volume 20, Article number: 882 (2020)
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